Clinical application of different doses of alfentanil combined with propofol in painless cystoscopy KANG
Shuai, PEI Da-qing, ZHOU Hong-mei, et al. Department of Anesthesiology, theSecond Af.liated Hospitalof Jiaxing University, Jiaxing, Zhejiang 314000, China
Abstract:
Objective To investigate the clinical effect of different doses of alfentanil combined with propofol in painless cystoscopy. Methods One hundred and five patients of both sexes, aged 30-75 years old, of ASA physical status I or III, scheduled for elective cystoscopy under intravenous general,were randomly divided into group A, group B and group C by random number table method (n=35 each). Groups A, B and C were anesthetized with alfentanil 5 μg/kg, 7.5 μg/kg and 10 μg/kg combined with propofol respectively, and the target sedation depth was MOAA/S ≤2 points. The incidence of hypoxemia, hypotension, bradycardia, involuntary movement events, sedation success rate, number of vasoactive drug users, propofol dosage, induction time, examination time, recovery time, operation time during cystoscopy were recorded. The incidence of posterior urinary tract irritation, moderate to severe urinary tract irritation and postoperative nausea and dizziness. Results The incidence of intraoperative hypoxemia in group C was significantly higher than that in group B (25.0% vs 3.2%, P<0.05); the incidence of hypotension in group A was signi.cantly higher than that in group B (32.4% vs 9.7%, P<0.05) , the incidence of bradycardia was signi.cantly higher than that in groups B and C (bothP<0.05); the incidence of urinary tract irritation in group A was signi.cantly higher than that in groups B and C (both P<0.05). The dosage of propofol, the number of vasoactive drugs and the recovery time in group A were signi.cantly higher than those in groups B and C (all P<0.05); the three groups were different in terms of sedation success rate, moderate to severe urinary tract irritation and satisfaction score. There were no statistical signi.cances (P>0.05). Conclusion Alfentanil 7.5 μg/kg combined with propofol anesthesia is safe and effective in painless cystoscopy, and the anesthesia effect is better.
