Clinical effect of early goal-directed sedation on postoperational patients with mechanical ventilation
SHU Kai-li,YAN Peng-bo,CAO Wen-li
Department of Respiratory and Critical Care Medicine, Tianjin Beichen Hospital，Tianjin 300400, China
Abstract:
Objective To investigate the clinical effect of early goal-directed sedation strategy (EGDS) in patients with intensive care unit (ICU) mechanical ventilation. Methods From January 2016 to June 2021, 84 non comatose patients with ICU who need to continue mechanical ventilation (MV) after endotracheal intubation were randomly divided into experimental group and control group. In the experimental group, dexmedetomidine was used as the main sedative and propofol assisted fine-tuning sedation; Midazolam was used as sedative in the control group. Results Compared with the control group, EGDS could increase the proportion of reaching the goal of shallow sedation (RASS score -2 ~ +1) within 48 hours and the passing rate of 24-hour spontaneous breathing test (SBT), and reduce the time of MV, ICU hospitalization, hospitalization and delirium (P<0.05). Conclusion On the basis of early analgesia, the EGDS scheme dominated by dexmedetomidine and assisted by propofol has good safety and effectiveness.
