Clinical Efficacy of External Application of Chinese Medicine on Postoperative Wound Healing of Hemorrhoids: A Meta-Analysis
YUE Hong，YANG Yang，WU Qin-ping
Abstract:
Objective To systematically evaluate the efficacy of external application of traditional Chinese medicine. Methods Searching medical-related journals in China and abroad from 2005 to 2021 through databases such as China Biology Medicine dis, PubMed, China Knowledge Network, Wanfang and Vipshop. The quality of the literature that met the inclusion criteria was evaluated according to the purpose of the study and by referring to the quality evaluation criteria provided in the Cochrane Handbook. Meta-analysis with sensitivity analysis using RevMan 5.4.1 software. Results The study evaluated 12 randomized controlled trials, which included a total of 1561 respondents, and the overall quality of the literature was ordinary. Meta results shows that topical application of external of Chinese medicine helps to shorten the healing time of patients’ wounds [SMD= -2.36, 95%CI (-3.05, -1.67), P< 0 . 001 ]; improved healing efficiency [RR= 0 . 20 , 95 %CI ( 0 . 07 , 0 . 37 ), P=0.004]; reduced VAS score 2 days after hemorrhoid surgery [SMD=-0.33, 95%CI (-0.54, -0.11), P=0.003]; reduced VAS score 6 days after hemorrhoid surgery [SMD=-0.83, 95%CI (-1.15,-0.50), P<0.001]; reduced interleukin-6 (IL-6) levels in serum [MD=-20.69, 95%CI (-32.58, -8.80), P=0.0006] and reduced serum levels of tumor necrosis factor (TNF-α) [MD=-12.87, 95%CI (-13.47, -12.28), P<0.001]，which the differences were statistically significant. Conclusion The external application of Chinese medicine is effective in promoting healing time of postoperative hemorrhoid wounds, improving efficiency and reducing patients' pain, which is worthy of clinical promotion.
