Meta Analysis of Ningmitai Combined with Levofloxacin in Treatment of Chronic Prostatitis
ZHANG Chen,XI Jin-bo,LUO Rui-xiang
Abstract:
Objective To evaluate the efficacy and safety of Ningmitai combined with levofloxacin in the treatment of chronic prostatitis based on meta-analysis. Methods Computer data retrieved from CNKI,WanFang,VIP,PubMed, Medline,Corchrane Library and Embase databases wascollectedbythe randomized controlled trials (RCTs) for chronic prostattis with Ningmitai combined with levofloxacin.The literature retrieval period was from the initial construction of the database to September 2020. Data was extracted according to the inclusion and exclusion criteria of diseases, and Meta analysis was carried out by using RevMan 5.3 software. Results A total of 18 RCTs were included,involving 2504 patients.Meta analysis results showed that compared with the control group,Ningmitai combined with levofloxacin could significantly improve the clinical efficacy of patients with chronic prostatitis:[OR=2.92, 95%CI(2.35,3.63), P<0.001], reduce NIH-CPSI score:[MD=-5.13, 95%CI(-8.72,-1.54), P<0.001], reduce the count of interleukin-2(IL-2): [SMD=-0.79, 95%CI(-0.97,-0.60), P<0.001], reduce the count of interleukin-6(IL-6): [SMD=-0.85, 95%CI(-1.04,-0.66), P<0.001] and reduce the incidence of adverse reactions:[RR=1.00,95%CI(0.58,1.72), P=1.00]. Conclusion Ningmitai combined with levofloxacin in the treatment of chronic prostatitis can significantly improve the clinical efficacy,reduce the NIF-CPSI score,eliminate inflammatory cells and reduce adverse reactions.
