A Data Mining-based Analysis of Medication Rules in Treating Pain after Anorectal Surgery by External Chinese Medicine
WANG Si-qian,XIE Dong,CAI Yan
Anorectal Department, Yichang Traditional Chinese Medicine Hospital, Three Gorges University, Yichang 443000, China
Abstract:
Objective To investigate the rule of external application of traditional Chinese medicine for postoperative analgesia in anorectal disease, in order to provide evidence and references for the clinical application of herbs and formulae. Methods Collecting and sorting the information about the treatment of pain after anorectal surgery related to external Chinese medicine in Chinese medicine literatures on databases including Chinese National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM), establishing a database of external traditional Chinese medicine (TCM) prescriptions for postoperative analgesia in anorectal diseases, and finally applying the relevant theories and techniques of data mining to analyze the medication rules of it. Results A total of 1124 formulae and 277 herbs were included in this database. The high frequency herbs included Cortex Phellodendri (Huangbo), Sophora flavescens (Kushen) and Mirabilite (Mangxiao). The properties of the herbs were mainly cold, warm and mild. The tastes of the herbs were mainly bitter, pungent and sweet. These herbs meridian tropism mainly belong to the liver, large intestine and stomach meridians. 39 core drug pairs and 5 herb suits association rules are identified by Apriori. A total of 8 clustering formulae and 4 new prescriptions are summarized according to cluster analysis. Conclusion ”If there is no communication, there will be pain, and if there is no nutrition, then pain” is the theoretical basis of traditional Chinese medicine about pain. The postoperative pain of anorectal disease was treated by clearing heat and dryness, cooling blood and detoxification, promoting blood circulation and removing blood stasis, dispelling wind and dredging collaterals, replenishing qi and nourishing blood. The results of this study can provide a reference for clinical research and the development of new drugs. Keywords: Data mining; anorectal disease; postoperative analgesia; medication rule
