Meta-analysis of Clinical Efficacy and Quality of Life of FufangBanmao Capsules Combined with Chemotherapy in the Treatment of Gastrointestinal Malignant Tumors
HE Guo-ping,ZHAO Xuan-zhu,WANG Hua-qing
Tianjin University of Traditional Chinese Medicine,Tianjin(301617),China
Abstract:
Objective To systematically evaluate the clinical ef?cacy and quality of life of FufangBanmao Capsules combined with chemotherapy in the treatment of gastrointestinal malignant tumors, and provide evidence-based medical evidence for the clinical use of FufangBanmao Capsules. Methods Retrieve CNKI, VIP, WangFang Data, Pubmed, Web of Science, Cochrane, Embase database through computer,A randomized controlled study on the treatment of gastrointestinal malignant tumors with FufangBanmao Capsules was collected, and the retrieval time was set from the date of the establishment of each database to july13, 2020. Statistical analysis was performed using RevMan 5.3 software, and Stata 14.0 software was used for metaregression analysis and publication bias assessment (Funnel chart method, Egger test). Results A total of 14 articles were included and a total of 1 110 patients were included. Meta analysis showed: KPS score (RR=1.30, 95%CI=[1.15,1.47]); adverse reactions (gastrointestinal reaction RR=0.43,95%CI=[0.27,0.69], bone marrow suppression RR=0.38,95 %CI=[0.17,0.85], neurotoxicity RR=0.45,95%CI=[0.28,0.75], liver and kidney damage RR=0.58,95%CI=[0.38,0.89]); among them nausea and vomiting RR=0.67, 95%CI=[0.55,0.82], diarrhea RR=0.65,95%CI=[0.45,0.94], leukopenia RR=0.46,95%CI=[0.34,0.62], thrombocytopenia RR=0.48,95%CI =[0.35,0.66]); the total clinical effective rate (RR=1.61,95%CI=[1.37,1.89]) is better than the control group;But in terms of immune function, the difference between the two groups was not statistically significant(CD3+:SMD= 0.7,95%CI=[-0.52,1.92], CD4+: SMD=-0.15,95%CI=[-1.76,1.46], CD8+:SMD= -0.60,95%CI=[-1.49,0.29], CD4+/CD8+:SMD= 0.96,95%CI= [-0.15,2.06]). After the sensitivity analysis, the result change is small, indicating that the effect value stability is high. Conclusion FufangBanmao Capsules combined with chemotherapy is superior to chemotherapy alone in improving patients’quality of life, improving clinical ef?cacy, and reducing adverse reactions. However, due to the limitation of the quality and quantity of the included studies, the above conclusions need to be veri?ed by adding more high-quality studies.
