Effects of Low Dose Dexmedetomidine Combined with Lidocaine on the Recovery Quality of Hypertension Patients Whom Extubated under Deep Anesthesia
ZUO Qin-rong,ZHANG Yi-hua,LUO Hui-yu
Abstract:
Objective To observe the effects of low-dose dexmedetomidine combined with lidocaine on the recovery quality of hypertension patients whom extubated under deep anesthesia. Methods Forty hypertension patients who underwent the elective laparoscopic general anesthesia surgery were selected. The patients were divided into two groups with random number table method, and each group included 20 cases. The dexmedetomidine combined with lidocaine group (DL group) used low-dose dexmedetomidine 0.3 μg/(kg?h)combined with lidocaine 1.5 mg/(kg?h), and the propofol group (P group) used propofol 4 mg/(kg?h). At each time point which after entering the room (T1), immediately after tracheal extubation (T2), 10 minutes after tracheal extubation (T3), and 30 minutes after tracheal extubation (T4), the MAP, HR, PaCO2, PaO2, blood glucose, the extubation time and recovery time, post-extubation complications, postoperative 30-minute VAS scores were observed and recorded. Results At time pionts of T4, the MAP of DL group was lower than that of P group (90.6±11.9 mmHg vs 97.2±7.3 mmHg), which the difference was statistically significant (P <0.05).At time pionts of T2, T3 and T4, the HR of DL group was lower than that of P group, which the difference was statistically significant (P <0.05). At time pionts of T3, the PaCO2 of DL group was lower than that of P group(45.6±2.3 mmHg vs 48.4±2.5 mmHg), and the PaO2 of DL group was higher than that of P group (89.5±4.9 mmHg vs 84.2±3.2 mmHg), which the difference was statistically significant (P <0.05). At time pionts of T4, blood glucose in DL group was lower than that in group P (7.2±1.4 mmol/L vs 8.7±0.8 mmol/L),which the difference was statistically significant(P <0.05). There was no significant difference in the extubation time between the two groups of patients(P>0.05). The recovery time of DL group was shorter than that of P group (2.9±1.8 min vs 4.1±1.7 min), which the difference is statistically significant (P<0.05). The incidence of tongue fall (0%) in DL group was lower than that in group P (25%), which the difference was statistically signi?cant (P<0.05). The postoperative 30-minute VAS scores (2.3±1.0) of DL group was less than that of P group (4.2±0.8), which the difference was statistically signi?cant (P<0.05). Conclusion Low-dose dexmedetomidine combined with lidocaine used for extubation under deep anesthesia in hypertension patients under general anesthesia, which can signi?cantly improve the recovery quality of patients during the awakening period from general anesthesia. It has good clinical application value.
