Strategy and Value of Antibiotics Use in Acute Simple Appendicitis
ZHANG Hong-jian,LI Rong-lin
Department of the Second Forensic Sursery, Tianjin Ninghe District Hospital, Tianjin 301500, China
Abstract:
Objective To explore the strategy and value of antibiotics use in patients with acute appendicitis. Methods Sixty patients with acute simple appendicitis admitted to our hospital from February 1st, 2016 to February 1st, 2019 were divided into control group (Surgical treatment) and observation group (treatment with antibiotics) according to the selected treatment plan, 30 cases/group. The clinically relevant indicators, clinical efficacy and complications in two groups after treatment were compared, and the levels of white blood cell count and inflammatory factors (IL-6, TNF-α, CRP)) before and after treatment were also compared. Results The normal time of body temperature recovery, time of getting out of bed and hospital stay in the observation group were signi.cantly shorter than those in the control group (P<0.05). There was no statistical difference between the two groups in the time required for pain relief (P>0.05). The clinical curative rate of the control group was 93.33% (27/30), higher than that of the observation group [76.67%, (23/30)] (P<0.05); the incidence of complications in the observation group was 6.67% (2/30), which was lower than that in the control group [13.33% (4/30)] (P<0.05). The white blood cell count and inflammatory factors in the two groups had no significant difference before treatment (P>0.05). After 1 week of treatment, the levels of white blood cell count, IL-6, TNF-α and CRP in the observation group were (8.07±0.82)×109/L, (27.66±4.85) ng/mL (1.48±0.33) mg/L and (60.54±12.87) mg/L, which were lower compared with the control group [(10.14±0.96)× 109/L, (49.78±5.37) ng/mL, (2.21±0.41) mg/L and (91.32±13.16) mg/L] (P<0.05). Conclusion Although there is a certain tendency to relapse, the use of antibiotics in patients with acute simple appendicitis can effectively improve the clinical indicators of patients, reduce the incidence of complications and reduce the in.ammatory response of patients, and the effect is acceptable.
