Effect of Ulinastatin Combined with Xuebijing on Severe Acute Pancreatitis
HU Yun-ming,CHAN Yun- feng,HUANG Pei-pei
Department of Hepatobiliary Surgery, the First Af?liated Hospital of Wenzhou Medical University, Wenzhou (325000), China
Abstract:
Objective To study the clinical efficacy of ulinastatin combined with Xuebijing Injection in the treatment of severe acute pancreatitis and its effect on oxidative stress and intestinal mucosal protection. Methods Totally 134 patients with severe acute pancreatitis were enrolled in this study. According to the random number table method, they were divided into control group (conventional treatment+ulinastatin) and treatment group (conventional treatment+ulinastatin combined with Xuebijing Injection), 67 cases in each group. The inflammatory factor indicators (IL- 6 , IL- 8 , TNF-α and CRP), oxidative stress indicators (SOD, MDA and NO), immune function indicators (CD3+, CD4+, CD8+ and CD4+/CD8+), indexes of intestinal mucosal damage (DAO, endotoxin and D-lactic acid), clinically relevant indicators and clinical efficacy in two groups were compared. Results After treatment, the levels of IL-6, IL-8, TNF-α and CRP in the treatment group were signi?cantly lower than those in the control group (P<0.05). The reduction of in?ammatory response in the treatment group was better than that in the control group; the SOD and NO levels in the treatment group were signi?cantly higher than those in the control group. In the treatment group, the MDA level was signi?cantly lower than that in the control group (P<0.05). The oxidative stress in the treatment group was signi?cantly better than that in the control group. The CD3+ in the treatment group was slightly higher than that in the control group, but there was no statistical difference (P > 0. 05); CD4+ and CD4+/CD8+ were significantly higher than those in the control group, CD8+ was signi?cantly lower than that in the control group (P<0.05). It can be seen that the treatment group was better than the control group in regulating the immune function of the body; the DAO, endotoxin and D-lactic acid indexes in the treatment group were signi?cantly lower than those in the control group (P <0.05), the effect of improving the degree of intestinal mucosal damage was better in the treatment group than that in the control group; the disappearance time of abdominal pain, disappearance time of abdominal distension and recovery time of serum amylase in the treatment group were signi?cantly shorter than those in the control group (P<0.05). The total effective rate of the treatment group was 96%, which was statistically different from the control group (P<0.05). Conclusion The clinical ef?cacy of ulinastatin combined with Xuebijing Injection in the treatment of severe acute pancreatitis is signi?cant, and it is more helpful to improve in?ammatory response, inhibit oxidative stress, improve immune function, better protect intestinal mucosa, and promote the recovery of patients.
