Department of General Surgery, Shanghai TCM-Integrated Hospital Af?liated to Shanghai University of Traditional Chinese Medicine, Shanghai（200080），China;Department of Gastroenterology, Shanghai Integrated Traditional Chinese and Western Medicine Hospital, Shanghai University of Traditional Chinese Medicine (Shanghai 200080);Surgery Department of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Shanghai 200032)
Abstract:
Objective To investigate the value of pepsinogen Ⅰ (PGⅠ)，pepsinogen Ⅱ (PG Ⅱ )， rat io of PGⅠ/ PGⅡ( PGR)， gast r i n- 17 and H. pylori-IgG in serum with different gastric mucosallesions. Methods From January 2016 to January 2018，a total of 2394 patients with digestive tract symptoms underwent gastroscopy. According to the results of endoscopic examination and pathological diagnosis, they were divided into four groups: 1376 cases of chronic non-atrophic gastritis, 708 cases of chronic atrophic gastritis, 265 cases of gastric ulcer and 45 cases of gastric cancer. Serological gastric biopsy was detected and analyzed. Results The serum levels of PG Ⅰ in chronic atrophic gastritis group was signi?cantly lower than those in chronic non atrophic gastritis group, gastric ulcer group and gastric cancer group (P<0.05)．The serum levels of PG Ⅱ and G-17 in gastric cancer group were signi?cantly higher than those in nonchronic atrophicgastritis group，chronic atrophic gastritis group and gastric ulcer group (P<0.05). PGR in gastric cancer group was signi?cantly lower than that of chronic non atrophic gastritis group, chronic atrophic gastritis group and gastric ulcer group (P < 0 . 05 ). H.pylori positive rates in chronic atrophic gastritis group and gastric cancer group were higher than those in nonchronic atrophicgastritis group and gastric ulcer group (P<0.05).Conclusion Serological gastric biopsy is closely correlated to gastric mucosal disease and can be used as an important screening tool for gastric disease.
