Clinical Controlled Study on Curative Effect of Integrated Chinese and Western Medicine Early Therapy in Severe Acute Pancreatitis
LI Zhen,GAO Feng,YU Song-xia,ZHU Zheng-yuan
Emergency Department, the First People's Hospital of Xiaoshan, Hangzhou (311200), China
Abstract:
Objective To observe the effect of integrated Chinese and Western medicine therapy for severe acute pancreatitis (SAP) in early stage. Methods One hundred and thirty-eight patients with SAP were divided into two groups randomly. All of the patients started the therapy within 48h after getting SAP. The control group had 68 patients, who were treated with the routine method, while the 70 cases in observation group were given routine therapy integrated with Chinese medicine oral application, enema, and topical application. The treatment for both groups lasted for 7 d as one course. The measurement included the levels of amylase (AMY) and high sensitive C-reactive protein (CRP) before and after the treatment for both groups, symptoms and signs of patients in both groups before and after the treatment, including the starting point of diarrhea, time period of relieving enteroplegia (relief of abdominal distension, recovery of bowel sound and anal exhaustion), time period of returning to normal body temperature, time period of abdominal pressure returning to predicted values and time period of APACHE II rate returning to predicted values, clinical effects, ICU transfer and length of stay of both groups. Results After the treatment, the levels of serum AMY and CRP of both observation and control groups decreased signi?cantly (P < 0.05). The most signi?cant decrease was observed during the treatment in observation group (P < 0.05). Compared to the control group, the observation group had signi?cant decrease in the starting time of diarrhea, time period of relieving enteroplegia, time period of returning to normal body temperature, time period of the abdominal pressure returning to the predicted value, and time period of APACHE II rate returning to the predicted value (P < 0.05). Moreover, the length of stay and rate of ICU transfer of the observation group were also less than those of the control group, and the overall clinical efficiency of the observation group was higher than that of the control group (P < 0 . 05 ). Conclusion The curative effect of integrated Chinese and Western medicine therapy for SAP is signi?cant. It could ef?ciently improve the recovery of gastrointestinal function and the outcomes of patients.
