Effect of Different Doses of Oxycodone on Postoperative Hyperalgesia Induced by Remifentanil in General Anesthesia Patients
SHAO Zhao-jun,WANG Ying-hu
Binhai Hospital, General Hospital of Tianjin Medical University, Tianjin (300480), China
Abstract:
Objective To observe the effect of different doses of oxycodone on postoperative hyperalgesia induced by remifentanil in general anesthesia patients, and select the best dose. Methods Fifty cases of elective hysterectomy under general anesthesia were randomly divided into five groups of A, B C, D and E, n=10. A group is control group, and the patients in B, C, D and E groups were injected with oxycodone (0.05, 0.1, 0.15 and 0.2 mg/kg).The recovery time and number of adverse events such as nausea, vomiting, dysphoria, respiratory inhibition, pruritus, and sufentanil consumption at the time of 1, 2, 4, 12 and 24 h after operation were recorded. Results The recovery time of E group was (21.8±7.2) min, longer than that of A, B, C and D groups (P <0.05). The sufentanil consumptions of D and E groups were (51.8±3.3) μg and (52.6±3.5) μg, lower than those of A, B and C groups (P<0.05). The number of adverse reactions in E group was 5, more than that of A, B, C and D groups (P<0.05). Conclusion Rational dose of oxycodone can effectively prevent remifentanil-induced hyperalgesia in early postoperative patients after general anesthesia, without prolonging the recovery time or increasing the incidence of adverse reactions, and the recommended dose is 0.15mg/kg.
