Clinical efficacy of Zhongtong Shenxiao powder in treating gouty arthritis
XU Chen,DING Xin-xiang,GU En-peng
Abstract:
Objective To evaluate the clinical efficacy and safety of the hospital-prepared formulation Zhongtong Shenxiao powder for gouty arthritis(GA) with damp-heat accumulation syndrome. Methods Based on real-world data, a retrospective analysis was conducted on the clinical data of 109 GA patients admitted to The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 2022 to March 2025. The Visual Analog Scale (VAS) scores, swelling scores, Traditional Chinese Medicine (TCM) syndrome scores, and adverse reactions were observed and compared before and after treatment. Results Post-treatment VAS scores, swelling scores, and TCM syndrome scores of GA patients significantly decreased (P <0.05). The total effective rate reached 92.7%. The median time to 50% pain relief was 2.0(2.0, 3.0) days, and only 3 cases (2.75%) experienced mild skin reactions. Subgroup analysis revealed that co-administration with Xinhuang Tablets enhanced TCM syndrome improvement (P <0.05), while other combined medications showed no significant impact (P >0.05). Conclusion Zhongtong Shenxiao Powder demonstrates efficacy in clearing heat, resolving dampness, activating blood circulation, reducing swelling, and alleviating pain. It is a safe and effective option for relieving acute symptoms in patients with GA and warrants clinical promotion. Future prospective studies are necessary to further validate these findings.
