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基于肠道微生态研究托里消毒散加减对肛周脓肿术后创面愈合的影响
刘艳,丁康,刘利峰
南京医科大学附属江苏盛泽医院肛肠外科江苏苏州 215228;南京中医药大学附属南京中医院肛肠外科江苏南京 210022
摘要:
目的:基于肠道微生态研究托里消毒散加减对肛周脓肿术后创面愈合的影响。方法:选取2023年1月—2024年6月本院收治的106例肛周脓肿患者,以随机数字表法分为观察组和对照组,每组53例。对照组行常规治疗,观察组在对照组基础上增加托里消毒散加减治疗,比较两组临床疗效、中医证候积分、创面愈合率、创面愈合状况评分、肠道菌群指标及治疗安全性。结果:观察组总有效率及术后3 d、7 d、14 d创面愈合率大于对照组,创面愈合时间短于对照组(P <0.05)。观察组中医证候各项积分、疼痛视觉模拟评分(VAS)、创面渗液、水肿评分小于对照组,肉芽组织得分高于对照组,差异均有统计学意义(P <0.05)。观察组乳酸杆菌、考拉杆菌的菌落数高于对照组,短芽孢杆菌、霍尔德曼氏菌的菌落数低于对照组,差异均有统计学意义(P <0.05)。两组不良反应发生率差异无统计学意义(P >0.05)。结论:托里消毒散加减可促进肛周脓肿术后创面的愈合,改善患者的中医证候和肠道微生态。
关键词:  肛周脓肿  肠道微生态  托里消毒散  创面愈合
DOI:10.3969/j.issn.1007-6948.2026.03.017
投稿时间:2025-12-02
基金项目:江苏省中医肛肠疾病临床医学创新中心重点项目(GCCXZX-2021);吴江区“科教兴卫”项目(WWK202220)
Effect of modified Tuoli Xiaodu powder on wound healing after perianal abscess surgery based on intestinal microecology
LIU Yan,DING Kang,LIU Li-feng
Abstract:
Objective To explore the effects of modified Tuoli Xiaodu powder on the wound healing of postoperative perianal abscesses. Methods A total of 106 patients with perianal abscess admitted to our hospital from January 2023 to June 2024 were selected and divided into an observation group and a control group, with 53 cases in each group. The control group received conventional treatment and intervention, while the observation group received additional modified Tuoli Xiaodu powder. The clinical efficacy, TCM syndrome scores, wound healing rate, wound healing status scores, intestinal flora indicators, and treatment safety were evaluated in both groups. Results The total effective rate, wound healing rate at 3 d, 7 d and 14 d after surgery in the observation group were all higher than those in the control group, and the wound healing time was shorter than that in the control group (P <0.05). The scores of various TCM syndromes, VAS, wound exudate and edema in the observation group were lower than those in the control group, while the score of granulation tissue was higher than that in the control group (P <0.05). The lactobacillus and koala bacillus in the observation group were higher than those in the control group, while the short bacillus and Holderman's bacillus were lower than those in the control group (P <0.05). There was no difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion The modified Tuoli Xiaodu powder can promote the healing of the postoperative wound in perianal abscesses, improve the patient's traditional Chinese medicine syndromes and intestinal microecology.
Key words:  Perianal abscess  intestinal microecology  Tuoli Xiaodu powder  wound healing

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