Early nutritional support and its association with clinical outcomes in severe acute pancreatitis
SHI Yan-ru,LIU Guo-xing,CHANG Yan
Abstract:
Objective To investigate the application of early nutritional support in patients with severe acute pancreatitis (SAP) and analyze its impact on clinical outcomes. Methods A retrospective analysis was conducted on 163 SAP patients admitted to Tianjin Nankai Hospital between January 2023 and December 2023. According to the nutritional support methods, the patients divided into an EN+PN group (early enteral nutrition combined with parenteral nutrition, n=91) and a PN group (parenteral nutrition alone, n=72).Compare the nutritional status, time to initiation of nutritional support, and energy and protein intake between the two groups of patients, and analyze the impact of achieving caloric goals in the EN+PN group on clinical outcomes. Results All SAP patients were at nutritional risk, with 67.5%(110/163) being at high nutritional risk. The incidence of early malnutrition and severe malnutrition was low. There was no significant difference in the timing of nutritional support initiation between the two groups. However, the energy and protein intake in the EN+PN group were significantly higher than those in the PN group (P <0.05). After one week of treatment, the nutrition calorie group showed a significantly greater reduction in C-reactive protein (CRP) levels compared to the non-compliance group(P <0.05), along with significantly higher levels of total protein (TP) and albumin (ALB) (P <0.05). Moreover, The clinical prognosis of the achievement group was superior to that of the non-achievement group (P <0.05). Conclusion Early enteral nutrition combined with parenteral nutrition can effectively improve the nutritional status of SAP patients, alleviate systemic inflammatory response, reduce the need for continued treatment and mortality, and ultimately improve clinical outcomes.
