Clinical effect and prognosis analysis of CT-guided microwave ablation and radiofrequency ablation in patients with peripheral non-small cell lung cancer
HOU Yong-le,DING Zhen-xing,LIU Sheng-jie
Abstract:
Objective To explore the clinical effect and prognosis of CT-guided microwave ablation and radiofrequency ablation in the treatment of patients with peripheral non-small cell lung cancer (NSCLC). Methods In 52 patients with peripheral NSCLC from June 2017 to June 2020, they were divided into microwave group (CT-guided microwave ablation), RF group (CT-guided radiofrequency ablation), 26 cases in each group. Compare two groups of surgical efficacy [disease control (DCR), disease remission (ORR)] and lung function [1 second forced expiratory volume (FEV 1), forced vital capacity (FVC) and maximum ventilation (MVV)], lung cancer tissue proliferation gene expression [lung cancer tissue F box-rich in leucine repeat protein 20 (FBXL20), granule protein precursor (PGRN), centromere-associated protein (Sgo 1), serum T953 induced glycolysis and apoptosis regulators (TIGAR) mRNA relative expression], tumor marker levels [serum epidermal growth factor receptor (EGFR) And carcinoembryonic antigen (CEA)], immune function index (serum CD3+, CD4+, CD8+), All patients were followed up for 3 years after surgery, The cumulative survival rates of the two groups were counted. Results There was no significant difference between OCR and DCR between the two groups (P > 0.05); The ablation time in microwave group was shorter than that in RF group (P <0.05); MVV was higher in the RF group than in the microwave group (P <0.05); The relative expression of TIGAR mRNA in the microwave group was lower than that in the RF group (P <0.05); There was no significant difference in serum tumor markers levels before and after treatment between the two groups (P > 0.05); The CD4+/CD8+ value in the RF group was greater than the microwave group (P <0.05); 1,2 and 3 year survival was 84.62% (22/26), 69.23% (18/26), 46.15% (12/26), The postoperative survival rates were 88.46% (23/26), 73.08% (19/26), and 53.85% (14/26). There was no significant difference in cumulative survival between the two groups (P > 0.05). Conclusion Compared with radiofrequency ablation, CT-guided microwave ablation can more effectively shorten the ablation time of peripheral NSCLC. However, radiofrequency ablation has higher improvement degree on lung function and immune function of patients, and the two surgeries have little difference in the prognosis of patients.
