Application of different doses of cyclopofol combined with remifentanil in painless induced abortion
ZHANG Ke,QI Qing-ling,YANG Ming-yu
Department of Anesthesiology, the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin300100, China
Abstract:
Objective To observe the effect of different doses of cyclopofol combined with remifentanil in painless abortion. Methods 119 patients, were selected for elective painless abortion. Patients were divided into 3 groups by random number table method: cyclopofol 0.3 mg/kg group (C1 group, n=40), cyclopofol 0.4mg/kg group (C2 group, n=40), and cyclopofol 0.5mg/kg group (C3 group, n=39). Groups C1, C2 and C3 were injected with remifentanil 1 μg/kg and cyclopofol 0.3, 0.4 and 0.5 mg/kg, respectively. If the patient has body movement during surgery, add 0.1 mg/kg of cyclopofol. If no more than one additional time is added within 10 minutes, sedation is successful. The successful rate of sedation, the number of additional cases of cyclopofol, anesthesia induction time, operation time and recovery time were recorded. Heart rate (HR), mean pressure (MAP), and blood oxygen saturation (SpO2) were recorded before anesthesia (T0), when eyelash reflex disappeared (T1), at the beginning of surgery (T2), and at recovery (T3). The incidence of adverse reactions such as body movement, hypoxemia and injection pain were recorded. Results Compared with C1 group, the success rate of sedation in C2 and C3 groups was significantly increased, and the proportion of drug supplementation was significantly decreased (P<0.05). There was no significant difference in induction time among the three groups (P>0.05). Compared with C1 group, the recovery time of C2 and C3 groups was longer (P<0.05). Compared with T0, HR and MAP in T1 and T2 groups decreased significantly, and SpO2 in C3 group decreased significantly (P<0.05). Compared with C3 group, SpO2 in C1 and C2 groups was significantly increased at T1 and T2 (P<0.05). Compared with C1 group, the incidence of body movement in C2 and C3 groups was significantly decreased (P<0.05). Compared with the other two groups, the incidence of hypoxemia in C3 group was higher (P<0.05). Conclusion cyclopofol 0.4 mg/kg combined with remifentanil is safer and more effective, with faster recovery and less incidence of adverse reactions.
