Based on serological IGFBP-2, circAGFG1 analysis of the prognosis of patients with adenocarcinoma of oesophagogastric junction
JIN Min-di,LI Yu-xian,LAI Hong
Abstract:
Objective To study the perioperative application of Huachansu injection in esophagogastric junction adenocarcinoma with nano-carbon lymph node tracing for radical surgery and its impact on HKDC1 and ANXA13 protein expression. Methods 80 patients who underwent radical surgery for esophagogastric junction adenocarcinoma at Jiangnan Hospital Affiliated to Zhejiang Chinese Medicine University from January 2018 to December 2020 were selected. Based on the different treatment methods, they were divided into a nano-group and a Huachansu group, with 40 cases in each group. The nano-group received surgical resection + nano-carbon tracing lymph node dissection, while the Huachansu group received perioperative Huachansu injection combined with surgical resection + nano-carbon tracing lymph node dissection. The two groups were compared in terms of lymph node detection, tumor marker levels, coagulation function, postoperative pathological staging, and HKDC1 and ANXA13 protein expression. Results The total number of lymph nodes, target lymph nodes, and peripheral lymph nodes in the Huachansu group were all lower than those in the nano-group (P<0.05). The levels of carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), and neuron-specific enolase (NSE) in the Huachansu group were all lower than those in the nano-group (P<0.05). The coagulation function in the Huachansu group was better than that in the nano-group (P<0.05). Compared with before treatment, both groups showed an increase in insulin-like growth factor binding protein (IGFBP)-3 and a decrease in circAGFG1 after treatment, with the Huachansu group showing a greater improvement (P<0.05). In terms of postoperative T staging, the Huachansu group had 18 cases of pT02 stage and 22 cases of pT34 stage, while the nano-group had 1 case of pT02 stage and 39 cases of pT34 stage, with a significant difference between the two groups (χ2=19.948, P=0.000), and no significant difference in postoperative N staging (P>0.05). The positive expression rates of HKDC1 in the Huachansu group and the nano-group were 42.5% (19/40) and 70.0% (28/40), respectively, with a significant difference between the two groups (χ2=4.718, P=0.040); there was no significant difference in the positive expression rate of ANXA13 (P>0.05). Conclusion Huachansu can effectively increase the number of lymph node dissections in esophagogastric junction adenocarcinoma patients undergoing nano-carbon lymph node tracing technology combined with radical surgery without affecting other surgical indicators, reduce tumor marker levels and the positive expression rate of HKDC1 protein, improve coagulation function, and have a significant downstaging effect, which can improve the quality of surgery
