《中国中西医结合外科杂志》杂志社

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复方黄柏液涂剂负压滴灌对压疮创面的治疗效果及对相关炎症因子的影响
刘海涛,韩志新,牛大伟
天津市第三中心医院整形美容科天津 300170;天津市重症疾病体外生命支持重点实验室天津 300170 ;天津市人工细胞工程技术研究中心天津 300170;天津市肝胆疾病研究所天津 300170;安阳市人民医院整形烧伤科河南安阳 455000

摘要:

目的:观察复方黄柏液涂剂联合封闭负压引流治疗压疮创面的效果及对相关炎症因子的影响。方法:选取 2017年 12月— 2022年 12月我院收治的压疮创面患者 90例，均使用封闭负压引流技术治疗创面，根据灌洗液不同，分为生理盐水组(A组)、庆大霉素组(B组)、复方黄柏液涂剂组(C组)每组 30例。对比不同灌洗液冲洗后三组患者治疗前、治疗后 7d、14 d、 21 d各项指标的变化，包括创面愈合情况、血清淀粉样蛋，白 A(SAA)、白细胞介素 -6(IL-6)及 C反应蛋白(CRP)水平，并对创面分泌物行细菌培养和药敏试验。结果:创面愈合情况评分:治疗后 7d、14 d、21 d各组创面愈合情况评分均较治疗前降低(P<0.05)，治疗后 14 d，B组、C组评分下降较 A组更明显(P<0.05)；而治疗后 21 d，C组评分下降较 A组和 B组明显(P<0.05)。相关炎症因子:治疗后 7d，A、B、C三组的血清 SAA、IL-6、CRP水平均较治疗前下降(P<0.05)B、C组较 A组水平更低(P<0.05)；治疗后 14 d，B、C组的 SAA、IL-6、CRP水平均较治疗后 7d进一步下降(P<0.05)而 A组的，SAA、IL-6、CRP水平与治疗后 7d比较差异无统计学意义(P>0.05)；治疗后 21 d，C组的 SAA、IL-6、CRP水平均较治，疗后 14 d进一步下降(P<0.05)而 A、B组的 SAA、IL-6、CRP水平与治疗后 7d相比较差异无统计学意义(P>0.05)。细菌学变化:治疗后 7d，A、B、C三组患者细，菌培养阳性比例均较治疗前有所下降(P<0.05)B、C组较 A组细菌阳性率更低(P<0.05)；治疗后 14 d，三组患者细菌培养阳性比例较治疗后 7d后均有下降(P<0.05)；治疗后，21 d，C组阳性比例较治疗后 14 d下降更明显(P<0.05)，细菌培养结果显示以革兰阴性菌为主，治疗后 14 d、21 d时， B组细菌对庆大霉素的耐药率明显高于 A组和 C组。结论:复方黄柏液涂剂滴灌联合封闭负压引流能改善压疮创面局部症状，有利于患者疾病转归，效果优于庆大霉素和生理盐水负压滴灌治疗。

关键词: 复方黄柏液涂剂封闭负压引流压疮炎症因子

DOI：10.3969/j.issn.1007-6948.2024.03.020

投稿时间：2023-12-24

基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20191274)；安阳市科技攻关项目(2021C01SF047,2023C01SF149)

The therapeutic effect of negative pressure drip irrigation with compound Huangbai liquid coating on pressure ulcer wounds and the influence of related inflammatory factors

LIU Hai-tao,HAN Zhi-xin,NIU Da-wei

Abstract:

Objective To explore the effect of compound Huangbai liquid coating combined with closednegative pressure drainage on pressure ulcer wounds and its impact on related inflammatory factors. Methods 90 patients with pressure ulcers were selected and treated with closed negative pressure drainage technology.They were divided into physiological saline group (group A), gentamicin group (group B), and compoundHuangbai liquid coating group (group C) based on different irrigation solutions, with 30 cases in each group.Compare the changes in various indicators of three groups of patients before treatment, 7 days, 14 days, and 21days after treatment, including wound healing, serum amyloid A (SAA), interleukin-6 (IL-6), and C-reactive protein (CRP) levels, and conduct bacterial culture and drug sensitivity tests on wound secretions. Results (1) Score of wound healing: On the 7th, 14th, and 21st days after treatment, the scores of wound healing in each group decreased compared to before treatment (P＜0.05). On the 14th day after treatment, the scores of group B and group C decreasedmore significantly compared to group A (P＜0.05); On the 21st day after treatment, the score of group Cdecreased significantly compared to group A and group B (P<0.05). (2) Related inflammatory factors: 7 days after treatment, the levels of SAA, IL-6, and CRP in groups A, B, and C decreased compared to before treatment P<0.05), while the levels in groups B and C were lower than those in group A (P＜0.05); On the 14th day after treatment,the levels of SAA, IL-6, and CRP in groups B and C further decreased compared to the 7th day after treatment(P＜0.05), while the levels of SAA, IL -6, and CRP in group A showed no statistically significant difference compared to the 7th day after treatment ( >0.05); On the 21st day after treatment, the levels of SAA, IL-6, and CRP in group C further decreased compared to the 14th day after treatment (P＜0.05), while the levels of SAA,

Key words: Compound Huangbai liquid coating closed negative pressure drainage pressure ulcers inflammatory factors

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