Study on the correlation between Helicobacter pylori infection and traditional Chinese medicine constitution and pathological types in patients with colon polyps
YIN Yao,CHEN Ming
Abstract:
Objective Analyze the correlation between Helicobacter pylori infection and traditional Chinese medicine constitution and pathological types in patients with colon polyps, providing theoretical basis for the prevention and treatment of colon polyps with traditional Chinese and Western medicine. Methods A total of 486 patients diagnosed with colonic polyps who visited Nankai Hospital in Tianjin from June 2020 to March 2023 were collected. They were divided into an Hp positive group and an Hp negative group based on Hp test results. General information, traditional Chinese medicine constitution classification, and colonoscopy pathology classification were collected. Using logistic regression to analyze the influencing factors of adenomatous polyps, constructing a risk prediction model to predict the probability of adenomatous polyps. Results Compared with the Hp negative group, the proportion of dampness heat and phlegm dampness in the Hp positive group of colon polyp patients increased (34.51% vs 15.38% and 22.57% vs 9.62%, P<0.05), while the proportion of qi stagnation and qi deficiency decreased (10.62% vs 27.69% and 6.64% vs 13.46%), with statistical significance; The proportion of males, multiple polyps, and adenomatous polyps in the Hp positive group was higher than that in the Hp negative group (P<0.05). The results of logistic regression analysis indicated that factors such as aging and Hp infection were independent risk factors for adenomatous polyps (P<0.05). The proposed risk prediction model for adenomatous polyps is Y=1/{1+e(-3.364 -0.410*X1+ 0.042*X2+0.421*X3+0.086*X4+0.854*X5-0.002*X6)}. The area under the ROC curve of the model is 0.687, with a sensitivity of 79.3% and a specificity of 49.7%. Conclusion There is a correlation between Hp infection in colon polyp patients and gender, traditional Chinese medicine constitution, number of polyps, and pathological type. The main physical types of colon polyp patients are dampness heat and phlegm dampness. Elderly and Hp infected colon polyp patients have more severe pathological types. Constructing a diagnostic prediction model for adenomatous polyps can predict the severity of the disease.
