Clinical observation on treatment of small cell lung cancer with chemotherapy combined with modified Bazhen decoction
WANGZhen-qiang,CHENJing-jing,WANGHong-liang
Abstract:
Objective To explore the effectiveness and safety of chemotherapy combined with or without modified Bazhen decoction in the treatment of small cell lung cancer (SCLC). Methods From January 2020 to June 2021, 120 SCLC patients admitted to Cangzhou integrated traditional Chinese and Western Medicine Hospital Affiliated to Hebei College of traditional Chinese medicine were collected and separated into two groups using the random number table method. The control group (n=60) was given EP chemotherapy (etoposide+cisplatin), and the study group (n=60) was combined with modified Bazhen decoction on the basis of the control group. The efficacy, CD cells, quality of life and adverse reactions were compared between the two groups. Results The objective response rate (ORR) of the study group was higher than that of the control group (P<0.05). After treatment, the control group had lower CD3+, CD4+ and CD4+/CD8+ than before treatment (P<0.05), and higher CD8+ than before treatment (P<0.05), the study group had higher CD3+, CD4+ and CD4+/CD8+ than before treatment (P<0.05), and lower CD8+ than before treatment (P<0.05). After treatment, the study group had higher CD3+, CD4+, CD4+/CD8+ than the control group (P<0.05), and lower CD8+ than the control group (P<0.05). After treatment, the scores of all dimensions of the EORTC-QLQ-C30 scale in the two groups were higher than those before treatment (P<0.05). The scores of all dimensions of the EORTC-QLQ-C30 scale in the study group were higher than those in the control group after treatment (P<0.05). The study group had lower total incidence of adverse reactions than the control group (P<0.05). Conclusion Modified Bazhen decoction combined with chemotherapy can improve the curative effect of SCLC patients, improve the immune function and quality of life of patients, and reduce the adverse reactions caused by chemotherapy.
