Effects of self-designed Jianpi Chuji formula combined with sintilimab and chemotherapy on patients with advanced non-small cell lung cancer
LIJin-hong,JIANGYue,MENGYa-nan
Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated TCM·WM·Hebei, Cangzhou, Hebei 061000，China
Abstract:
Objective To explore the effects of self-designed Jianpi Chuji formula combined with sintilimab and chemotherapy on disease control rate, traditional Chinese medicine syndrome score, and untoward reactions in patients with advanced non-small cell lung cancer. Methods From October 2020 to October 2022, 102 patients with advanced non-small cell lung cancer accepted by our hospital were randomly separated into an observation group and a reference group, with 51 patients in each group, the reference group was given sintilimab, while the observation group was treated with a combination of self-designed Jianpi Chuji formula based on reference group. The clinical efficacy, the TCM symptom scores, tumor marker levels before and after treatment, and untoward reactions were compared between the two groups. Results The effective rate (47.06%) and disease control rate (78.43%) of the observation group were obviously higher than those of the reference group (P<0.05). After treatment, the TCM symptom scores in the observation group were obviously lower than those in the reference group (P<0.05). After treatment, the levels of serum ferritin (SF), squamous cell carcinoma antigen (SCCA), and carcinoembryonic antigen (CEA) in both groups were obviously lower than those in the same group before treatment, the levels of SF, SCCA, and CEA in the observation group were obviously lower than those in the reference group. The total incidence of reduced white blood cell count, nausea, and vomiting symptoms in the observation group was obviously lower than that in the reference group (P<0.05). Conclusion The combination of self-designed Jianpi Quji formula and sintilimab has a good therapeutic effect on advanced non-small cell lung cancer patients, can improve their traditional Chinese medicine symptoms, and has high safety.
