Study on the correlation between gallbladder cholesterol stones and low total cholesterol and low risk of cardiovascular and cerebrovascular diseases
XU Da-hui,CUI Nai-qiang,NIU Kai-jun
Abstract:
Objective To explore the possible relationship of cholelithiasis to cardiovascular diseases (CVD). Methods The study population comprises 22 150 in-patients at Tianjin NanKai hospital from January 2011 to December 2012. All participants claimed data including age, gender, hypertension, diabetes mellitus, hyperlipidemia and metabolic factors, such as fasting blood glucose, triglyceride and total serum cholesterol were searched. Multivariate Logistic regression models were used to assess the adjusted associations of Gallstone disease (GD) to CVD. Results There were 8 032 GD cases with an average age of 56.8 years (95%CI 56.4-57.5) compared to an average age of 57.3 years (95%CI 57.0-57.6) in 14 118 non-GD group (P＞0.05). Significant differences were found in the proportion of female patients between the groups (P<0.001). The cholelithiasis group had a borderline decrease in the prevalence of hypertension and significant decrease (P<0.001) in the prevalence of diabetes compared to the non-cholelithiasis group. No significant differences were found in the prevalence of hyperlipidemia between the groups (P＞0.05). Subjects with GD had a lower prevalence of CVD (29.5%) than those of the controls (43.2%，P<0.001). The difference remained when CHD and stroke constituted CVD were considered separately. Serum total cholesterol levels were lower in the cholelithiasis patients than those without disease (4.31 mmol/L vs 4.34 mmol/L, P<0.001). Conclusion Cholelithiasis is associated with decreases in both serum total cholesterol and the prevalence of CVD.
