Meta-analysis of treating stress ulcer after stroke by Qingre Liangxue method
ZHAO Cong,WANG Ge-sheng
Abstract:
Objective To analyze the clinical efficacy and advantages of Qingre Liangxue method in the treatment of stress ulcer after stroke. Methods The Chinese medical literature database, VIP database, Chinese Journal Full-text Database, Wanfang database, PubMed, Cochrane Library database were searched by computer from database establishment to November 2022. Meta-analysis was performed using RevMan 5.3 software after two reviewers independently screened the literatures, extracted the data and evaluated the bias of the included studies. Results Ten randomized controlled trials were included, including 488 patients in the observation group and 566 patients in the control group. Meta-analysis showed that compared with the control group, the total effective rate of TCM cooling blood to stop bleeding combined with conventional western medicine in the treatment of post-stroke stress ulcer patients was higher [OR = 3.99, 95% CI (2.40, 6.63), P < 0.001], lower mortality [OR = 0.43, 95% CI (0.28, 0.66), P< 0.001], faster hemostasis time [MD = -15.73, 95% CI (-19.40, -12.06), P < 0.001], higher recovery rate [OR = 2.59, 95% CI (1.58, 4.23), P < 0.001], shorter recovery time [MD = -18.58, 95% CI (-28.48, -8.67), P< 0.001], lower incidence of adverse reactions [OR = 0.19, 95% CI (0.08, 0.49), P< 0.001]. In terms of gastric pH after treatment, there was no significant difference between the observation group and the control group [MD = 0.77, 95% CI (-0.07, 1.60), P = 0.07]. Conclusion The method of clearing away heat and cooling blood combined with conventional western medicine can improve the effective rate, reduce the mortality, reduce the incidence of adverse reactions, shorten the time of hemostasis, improve the recovery rate of coma patients and shorten the recovery time of awake time. However, the quality of the included articles is low, and higher quality RCTs are needed for validation.
