Plasma fibrinogen, fibrinogen degradation products and D-dimer levels before treatment predict prognosis in non-small cell lung cancer
CHE Juan-juan,LI Hui-hui,ZHEN Hong-chao
Abstract:
Objective To investigate the relationship between Fbg, FDP, D-dimer level before operation and prognosis and clinical stage of non-small cell lung cancer. Methods A retrospective analysis of 377 NSCLC patients with definite pathological diagnosis in Beijing Hospital affiliated to Capital University from July 2013 to November 2017 were conducted. The patients were grouped according to the preoperative Fbg, FDP and D-dimer levels, and the normal values were set as Fbg<3.498 g/L, FDP<3.165 g/L, and plasma D-dimer ≤289.005 μg/L. Those with all three indexes being normal were considered as low-risk group, those with only 1-2 items higher than normal were considered as medium-risk group, and those with all three indexes higher than normal were considered as high-risk group. Clinical statistics were used to analyze the clinicopathologic characteristics of each group, and the 5-year survival rate of the patients was analyzed. The differences in survival curves among the groups were compared, and the influence of preoperative plasma Fbg, FDP and D-dimer levels on the prognosis of the patients was analyzed by multi-factors. Results Preoperative FDP, Fbg and D-dimer levels were correlated with age, smoking history, pathological type, pathological stage, tumor size and postoperative chemotherapy. The 5-year OS rate was statistically different among all groups, and the survival curve suggested that the high-risk group had a poor prognosis (low-risk group =94.40%; Intermediate risk group =82.40%; High-risk group =64.40%, P<0.001). Multivariate analysis showed that tumor size and risk were independent factors affecting the prognosis of patients with complete NSCLC. Conclusion The combined detection of FDP, Fbg and D-dimer can be used as a potential indicator to predict the prognosis of patients with NSCLC after complete resection.
