Effect of CT guided sclerosing agent and body surface localization combined with single hole thoracoscopic anatomical partial pneumonectomy on patients with non-small cell lung cancer
MA Bao-ke,ZHANG Yang,SHANG Hui-ying
Department of Thoracic Surgery, Handan First Hospital, Handan 056002,China
Abstract:
Objective To investigate the effect of CT guided sclerosing agent and body surface localization combined with single hole thoracoscopic anatomical partial resection on patients with non-small cell lung cancer (NSCLC). Methods 202 patients with NSCLC treated in our hospital from March 2019 to December 2021 were divided into observation group (n = 110) and control group (n = 92) according to the odd and even number at the end of the inpatient medical record number. The patients in both groups were treated with anatomical cuneiform resection under single hole thoracoscope, the observation group was treated with CT guided sclerosing agent and body surface positioning, the control group was treated with body surface positioning, The operation time, intraoperative bleeding, lung function, tumor markers, prognosis before and after operation and other indexes of two groups were observed. Results The operation time, amount of intraoperative bleeding and postoperative drainage volume in the observation group were (154.31±34.45) min, (270.50±40.06) mL, (410.50±91.14) mL respectively, which were significantly less than those in the control group (P < 0.05). The drainage time of thoracic catheterization was (5.60±1.09) d, which was significantly shorter than that in the control group (P <0.05). The success rate of one-time localization in the observation group was 98.18%, which was significantly higher than that in the control group (P<0.05). One month after operation, maximum ventilation volume (MVV), peak expiratory flow rate (PEF), forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) in the observation group were (77.79±8.16)L, (58.87±6.03) L/min, (1.81±0.44)L and (2.60±0.81)L respectively, which were significantly higher than those in the control group (P < 0.05). There was no significant difference in soluble fragment of cytokeratin 19 (CYFRA21-1), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199) and squamous cell carcinoma antigen (SCC) at one month after operation between the observation group and the control group (P < 0.05). The QlQ-C43 scale scores of the observation group and the control group were significantly different at one month after surgery (P > 0.05). There were no significant differences in median disease-free survival and overall survival between the observation group and the control group (P > 0.05). Conclusion CT guided sclerosing agent and body surface localization combined with single hole thoracoscopic anatomical partial pneumonectomy has less lung function injury in patients with NSCLC, but it has no significant effect on the prognosis of patients.
