ω-Application value of fish oil fat emulsion injection combined with enteral nutrition in patients with sepsis
WU Yue-ming,XU Jun-long,LOU Tian-zheng
Department of ICU, Lishui People’s Hospital, Lishui, Zhejiang 323000 China
Abstract:
Objective To explore ω- Application value of fish oil fat emulsion injection combined with enteral nutrition in patients with sepsis. Methods 72 patients with sepsis from March 2018 to February 2021 in our hospital were selected and divided into control group (n = 37) and observation group (n = 35) by coin tossing. The control group received standard treatment according to guidelines for the emergency management of sepsis/septic shock in China (2018), and the observation group was added on the basis of the control group ω-3 fish oil fat emulsion injection. The 28-day mortality risk, APACHE II score, CRP level and ICU stay time of the two groups were compared. Results Ten cases (27.03%) died within 28 days in the control group and 7 cases died (20.00%) in the observation group. There was no significant difference in 28 day mortality between the two groups(χ2=0.36, P=0.55)；There was no significant difference in 28 day mortality risk between the two groups by log rank test (HR = 0.71, 95% CI: 0.27-1.8, P = 0.47). The average time of death in the control group and the observation group was (15.03±6.27) days and (15.64 ± 4.81) days, with no significant difference (t = 0.22, P = 0.83). After treatment, the APACHE II score of the two groups showed a downward trend. From the 6th day (14.21±2.56) vs (12.12±2.54) to 7th day (13.86±2.25) vs (11.67±2.32), APACHE II score of the two groups showed statistical difference (P < 0.05). After treatment, the serum CRP score of the two groups showed a downward trend. From the third day (69.88±11.21) vs (70.23±10.66) mg/L, the serum CRP level of the two groups showed statistical difference (P < 0.05). The average ICU stay time of patients in the observation group and the control group was (15.22 ± 4.03) and (16.87 ± 4.22) days. The observation group was shorter than the control group, and there was significant difference (t=1.69, P < 0.05). Conclusion ω-3 fish oil fat emulsion injection combined with enteral nutrition can reduce the level of serum CRP and APACHE II score, improve the inflammatory state and shorten the stay time in ICU, but it cannot reduce the risk of 28 day death.
