Comparison of the effects of Wuda granules and alvimopan on gastrointestinal migrating motor complex in postoperative ileus model mice
CHEN Qi-cheng,JIANG Zhi,CHEN Zhi-qiang
Abstract:
Objective To observe the effect of Wuda granules and alvimopan on gastrointestinal migrating motor complex (MMC) movement in postoperative ileus model mice. Methods 15 adult C56BL/6 mice were implanted with miniature stress sensors on the surface of the gastric antrum and duodenal serosa, and randomly divided into a control group, POI-Wuda granules group, and POI-Avimopan group, with 5 mice in each group, to compare the effects of Wuda granules and Avimopan on postoperative gastrointestinal MMC motility in POI mice. Results The control group of mice showed typical MMC in the gastric antrum and duodenum. After intestinal manipulation, the MMC cycle in the gastric antrum and duodenum of mice was disrupted, and irregular contractile waves appeared. Compared with the control group, the amplitude, frequency, and amplitude index of contractions decreased (p<0.001). Sequential administration of Wuda granules (0.75, 1.5 and 3 g/kg) induced high-frequency and high amplitude MMC III phase like contractions, with significant increases in contraction frequency, amplitude, and amplitude index compared to the baseline values before administration (p<0.001).Sequential administration of alvimopan (0.25, 0.5 and1 mg/kg) did not significantly enhance gastric antral and duodenal contractions, with no significant differences in contraction frequency, amplitude, and amplitude index compared to before administration. Conclusion Intestinal manipulation leads to impaired gastrointestinal MMC motility in mice. Wuda granules improve postoperative gastrointestinal motility by inducing MMC phase 芋contraction, while the effect of alvimopan in treating POI is not directly enhanced by postoperative gastrointestinal motility.
