Study on the correlation between blood lipid level and condition changes in the middle stage of bacterial liver abscess with severe heat poisoning syndrome
CHEN Di,CHEN Ming
Abstract:
Objective To study the correlation between blood lipid level, inflammation level and disease score in patients in the middle stage of bacterial liver abscess with Severe Heat Poisoning Syndrome, and the changes of blood lipid level after different treatment schemes. Methods A retrospective study was carried out on 121 patients in the middle stage of bacterial liver abscess with Severe Heat Poisoning Syndrome who were hospitalized in Tianjin Hospital of ITCWM Hospital. Based on the presence of sepsis and septic shock prior to treatment, the patients were divided into three groups: the non-septic group (27 cases), the septic group (non-septic shock) (73 cases), and the septic group (septic shock) (21 cases). Furthermore, patients were categorized by treatment regimen into a Western medicine treatment group (38 cases) and a integrated traditional Chinese and Western medicine treatment group (83 cases). Then analyze their blood lipid level, inflammation level, SOFA score, APACHE Ⅱ score, risk factors of sepsis and changes of indicators after western medicine treatment and integrated traditional Chinese and western medicine treatment. Results In this study, 121 patients were included. Before treatment, HDL and LDL was negatively correlated with Leukocyte N%, CRP, PCT, SOFA score and APACHE Ⅱ score. Multivariate Logistic regression analysis showed that HDL, PCT and APACHE Ⅱ scores were risk factors for sepsis. And LDL, PCT, APACHE Ⅱ scores were risk factors for septic shock. The further study of treatment groups showed that the absolute values of ΔHDL and ΔCRP in the treatment group of ITCWM before and after treatment was higher than that of the Western medicine treatment group[(+0.54±0.18)mmol/L,(-164.10±75.50)mg/L vs (+0.12±0.14)mmol/L,(-95.94±68.98)mg/L], and the difference was statistically significant (P<0.05). Conclusion The change of blood lipid level in patients in the middle stage of bacterial liver abscess with Severe Heat Poisoning Syndrome can prompt the severity of the disease, and the treatment of this kind of patients with ITCWM has obvious advantages in accelerating the recovery of inflammation, promoting the recovery of the disease, shortening the course of disease and reducing the hospitalization expenses.
