Application of closed -loop target controlled infusion intravenous anesthesia of ciprofol under BIS monitoring in patients undergoing endoscopic retrograde cholangiopancreatography
JIN Yun-min,YANG Yan-wei,LIU Ji
Abstract:
Objective To investigate the efficacy and safety of application of closed-loop target controlled (CL -TCI) infusion intravenous anesthesia of ciprofol under BIS monitoring in patients undergoing endoscopicretrograde cholangiopancreatography(ERCP). Methods Sixty ASA II-III patients undergoing elective ERCP inour hospital from January 2023 to June 2024 were enrolled in this retrospective study. Patients were divided intotwo groups based on the use of different sedative drugs: the propofol group (group P, n=30) and the ciprofol group (group C, n=30). MAP, HR and SpO2 were recorded before induction of anesthesia (T0), after induction of anesthesia(T1)，at time of reaching duodenal papilla(T2), at time of withdrawing the endoscope(T3). Induction time， awakening time, the application of vasoactive drugs, injection pain, respiratory depression, postoperative vomiting,hypotension and bradycardia were recorded. Results MAP, HR, SpO2 at T1 and T2 in group C was significantly higher than in group P(P<0.05), but had no significant difference at T 0 and T3 in both groups(P>0.05). Inductiontime was longer and awakening time was shorter in group C than in group P. Application of vasoactive drugs,injection pain, respiratory depression, postoperative vomiting, hypotension, bradycardia in group C were less than in group (P<0.05). Conclusion Both CL-TCI of ciprofol and propofol can achieve good sedation effects.Ciprofol provides more stable hemodynamic levels, shortens awakening time, and reduces the incidence ofadverse events. Therefore, ciprofol CL-TCI intravenous anesthesia under BIS monitoring can be safely applicatedin patients undergoing ERCP.
