Meta-analysis on the necessity of hepatectomy for T2 stage gallbladder cancer
SUN Zhe,XU Xin-sheng,ZHAO Hong-zhi
Tianjin Hospital of Integrated Traditional Chinese and Western Medicine , Tianjin300100, China
Abstract:
Objective To investigate the impact of hepatectomy on the prognosis of patients with T2 stage gallbladder cancer through Meta-analysis. Methods Databases including PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, and VIP Database were searched. The search terms included: gallbladder carcinoma, surgery, cholecystectomy, radical cholecystectomy, hepatectomy, liver resection. Comparative analysis was conducted on indicators such as overall survival, disease-free survival, postoperative complication rate, and mortality within 30 days after surgery between the hepatectomy group and the non-hepatectomy group. Meta-analysis was performed using RevMan 5.4 software. Results A total of 20 studies involving 3222 patients were included, with 1959 patients in the hepatectomy group and 1263 patients in the non-hepatectomy group. Meta-analysis results showed no significant statistical differences in postoperative overall survival rate (RR=0.93, 95%CI: 0.77-1.12, P =0.44), postoperative disease-free survival rate (RR=1.11, 95%CI: 0.84-1.47, P =0.45), postoperative complication rate (RR=2.00，95%CI:0.71-5.62，P =0.19, and mortality within 30 days after surgery (RR=0.90, 95%CI: 0.10-8.02, P =0.92) between the hepatectomy group and the non-hepatectomy group. Conclusion Hepatectomy does not benefit patients with T2 stage gallbladder cancer.
