Effect of oxycodone successive subtraction method background infusion for postoperative analgesia in old patients undergoing total hip arthroplasty
HU Hui-ying,LI Shu-ting,LUO Zi-su
Anesthesiology Department of Central Theater Command General Hospital, Wuhan (430010), China
Abstract:
Objective To observe the effect of oxycodone successive subtraction method background infusion for postoperative analgesia in old patients undergoing total hip arthroplasty. Methods Ninety patients undergoing total hip arthroplasty,from April 2020 to September 2023.33 males,57 females,aged 62~78 years,falling into ASA physical status I or Ⅱ, were randomly decided into the group Q1 (n=30), the group Q2 (n=30),and the group E(n=30). The patients in group S recieved sufentayl 2.0 ug/kg + tropisetron 10 mg + 0.9% normal saline to 100 mL.The patients in group Q1 and group Q2 received hydromorphone 0.20 mg/kg +tropisetron 10 mg+0.9% normal saline to 100 mL. The analgesic parameters of group S and group Q1 were background infusion rate of 2 mL/h, PCA amount of 2 mL, and lock-up time of 10 min. The analgesic parameters on the first 12 h after operation of group Q2 were background infusion rate of 2 mL/h, every 12 h later, the background infusion decreased by 20%, PCA amount of 2 mL, and lock-up time of 10 min. Recorded the VAS scores of the three groups the VAS scorses at 2 h,6 h,12 h and 24 h after surgery and the effective compression of PCIA , the amount of drug use within 48 hours points after surgery ,Ramsay sedation scores, and adverse reactions such as respiratory depression, nausea, vomiting, itching. Results The VAS score in group S T2-T4 were higher than those in group Q1 and group Q2 (P< 0.05). Ramsay sedation score in group S T2-T4 were lower than those in group Q1 and group Q2 (P< 0.05).The effective compression frequency and the volume of drug use of group Q1 and group Q2 within 48 hours were lower than that in group S (P< 0.05). The volume of drug use and postoperative nausea and vomiting in group Q2 were higher than that in group Q1 (P< 0.05). Conclusion Oxycodone successive subtraction method background infusion for postoperative analgesia in old patients undergoing total hip arthroplasty can obtain satisfactory analgesia effect, reduce the dosage of drugs and reduce the adverse reaction.
