Serum D -dimer, thromboxane B2 combined with 6-K-PGF1aprediction of deep vein thrombosis in lower limbs after joint replacement of artificial knee
ZHAO Yun,HU Wen-jin,ZHAO Xiao-hu
Tianjin Institute of Traditional Chinese Medicine Affiliated Hospital, Tianjin300120, China
Abstract:
Objective To explore the predictive value of serum D-dimer (D-D), thromboxane B2 (TXB2) combination 6-keto-prostaglandin F1a(6-K-PGF1a) for lower limbs deep vein thrombosis (DVT) after total knee arthroplasty (TKA). Methods 156 patients who plan to undergo TKA were selected, and they were divided into concurrent group and non-concurrent group according to whether postoperative lower limb DVT occurred. The serum levels of D-D, TXB2, 6-K-PGF1abefore and 24 hours after surgery were detected and compared between the two groups. The influencing factors of lower limb DVT after TKA was analyzed by Logistic regression, and the predictive value of the postoperative 24-hour serum D-D, TXB2 and 6-K-PGF1alevels of DVT in lower limbs after TKA was analyzed by the receiver operating characteristic (ROC) curve. Results The levels of serum D-D and TXB2 in concurrent group at 24 hours after surgery were higher than those in nonconcurrent group (P< 0.05), and the serum 6-K-PGF1alevel at 24 hours after surgery was lower than that in nonconcurrent group (P< 0.05). Logistic regression analysis showed that the levels of serum D-D, TXB2 and 6-K-PGF1a at 24 hours after surgery were the influencing factors for lower limb DVT after TKA (P< 0.05). The ROC curve analysis showed that the sensitivity and area under curve of serum D-D, TXB2, and 6-K-PGF1alevels to predict DVT of lower limbs after TKA were 94.23% and 0.925 respectively, which were higher than the independent prediction of each index (P< 0.05), and the specificity was basically consistent with the individual predictions of each indicator. Conclusion The levels of serum D-D, TXB2, 6-K-PGF1aat 24 hours after surgery have certain predictive value for lower limb DVT after TKA, but the combined predictive value of the three is higher.
