Feasibility study on evaluating the therapeutic effect of traditional Chinese medicine for nourishing Yin and clearing heat on premature ejaculation of Yin deficiency and hyperactive fire type based on penile sympathetic skin response
CHEN Min-Hui,HUANG Xiao-Jun,LI Zhe-Yang
The Second Affiliated Hospital ZheJiang University School of Medicine, HangZhou (31000), China
Abstract:
Objective Exploring the clinical efficacy of traditional Chinese medicine for nourishing yin and clearing heat [modified Zhibai Dihuang decoction] in the treatment of premature ejaculation patients with Yin deficiency and hyperactive fire, and the application value of penile sympathetic skin response (PSSR) evaluation in this regard. Methods 96 patients with primary premature ejaculation(PPE) of Yin deficiency and hyperactive fire type, in outpatient clinics were selected from January 2022 to Decembe 2023, randomly divided into two groups: the treatment group (traditional Chinese medicine for nourishing yin and clearing heat) and the control group (50 mg of sertraline hydrochloride tablets), with a treatment period of 8 weeks for both groups. Compare the intravaginal latency time (IELT), premature ejaculation diagnostic scale (PEDT), International Erectile Function Index-5 (IIEF-5), and PSSR latency and amplitude detected by electromyography evoked potential before and after treatment. Results Before and after treatment, there was no statistically significant difference in IELT, PEDT, PSSR amplitude, and PSSR latency in the two groups (P>0.05); After treatment, the incubation periods of LELT and PSSR in both groups were higher than before treatment, while the amplitudes of PEDT and PSSR were lower than before treatment, the difference is statistically significant (P<0.05). There was no statistically significant difference in IIEF-5 between the two groups before and after treatment (P>0.05). Conclusion Positive therapeutic effect of Traditional Chinese Medicine of nourishing yin and clearing heat in the treatment of primary premature ejaculation. The latent period of PSSR is a relatively objective evaluation index for evaluating the clinical efficacy of Traditional Chinese Medicine in the treatment of primary premature ejaculation.
