Expression and correlation of PIM-1 and Eg5 proteins in prostate cancer
LUO Rong-li，XU Min，ZHANG Chun-ting
Abstract:
Objective To detect the expression of serine threonine kinase-1(PIM-1) and kinesin-5 (Eg5) proteins in prostate cancer and to investigate their correlation with the clinicopathology of prostate cancer. Methods The expression of PIM-1 and Eg5 protein in 81 cases of prostate cancer and 43 cases of benign prostatic hyperplasia were detected by immunohistochemical streptavidin-perosidase method. The relationship between the positive rate of PIM-1 and Eg5 protein expression and the clinicopathological characteristics of prostate cancer were analyzed by chi square test. The correlation between PIM-1 and Eg5 protein in prostate cancer was evaluated by Pearson correlation analysis. Results The expressions of PIM-1 and Eg5 proteins in prostate cancer were significantly higher than those in benign prostatic hyperplasia (P<0.05). The positive rates of PIM-1 and Eg5 protein expressions were related to Gleason score, clinical stage, preoperative PSA and 5-year biochemical recurrence (P<0.05). They were not related to the patient's age (P>0.05). Biochemical relapse with high positive rate of PIM-1 and Eg5 protein expression was higher than that with low positive rate of PIM-1 and Eg5 protein expression (P<0.05). Pearson correlation analysis showed that PIM-1 and Eg5 proteins were positively correlated in prostate cancer (r=0.825, P<0.05). Conclusions PIM-1 and Eg5 genes may be related to the evolution and progression of prostate cancer, and joint detection may improve the prediction of prostate cancer.
