Evaluation of lymph node metastasis and its relationship with prognosis in breast cancer patients by combined detection of serum insulin-like growth factor-1, hepatocyte growth factor and tumor stroma ratio
LIANG Qiu,JIAO Ming-yuan,LI Zhi
Breast Department of Beijing Tongzhou District Maternal and Child Health Hospital, Beijing101101, China
Abstract:
Objective To investigate the value of serum insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF) and tumor stroma ratio (TSR) in the diagnosis of lymph node metastasis in breast cancer and their relationship with prognosis. Methods A retrospective study was conducted to select 120 patients with breast cancer who were admitted to the Breast Department of Tongzhou District Maternal and Child Health Hospital from June 2015 to August 2017 as the study subjects. According to the pathological results after surgery, the patients were divided into 24 patients with recurrent metastasis and 96 patients without recurrent metastasis, and the serum IGF-1, HGF, TSR values of the two groups were compared, The value of three indicators in the diagnosis of lymph node metastasis in breast cancer patients was analyzed by subject work curve; Logistic regression model was used to analyze the relationship between the pathological characteristics, treatment methods, IGF-1, HGF, TSR and the prognosis of breast cancer patients. Results IGF-1 and HGF in patients with lymph node metastasis of breast cancer were significantly higher than those in patients without metastasis, and TSR in patients with breast cancer metastasis was significantly lower than those in patients without metastasis (P<0.05); The AUC values under the ROC curve of IGF-1, HGF and TSR for diagnosis of lymph node metastasis in breast cancer were 0.837 (0.766-0.907), 0.842 (0.773-0.911) and 0.880 (0.821-0.938), respectively; Logistic regression model: TNM stage ≥ stage II, lymph node metastasis, elevated IGF-1 level, elevated HGF level, and low TSR level will increase the risk of recurrence and metastasis of breast cancer patients after surgery (P<0.05). Conclusion The increase of IGF-1, HGF and TSR levels and the decrease of TSR will increase the risk of postoperative recurrence in breast cancer patients. Preoperative examination of IGF-1, HGF and TSR can evaluate whether lymph node metastasis occurs, which has certain reference value for the formulation of surgical plan.
