Effect of early application of Qingre Tongxia method combined with acupuncture on inflammatory response syndrome of mild to moderate acute acpancreatitis
XU Wen-jie,TANG Zhang-qing,BAO Ji-feng
Department of Modern Surgery, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract:
Objective To explore the effect of early application of Qingre Tongxia method combined with acupuncture oninflammatory response syndrome of mild to moderate acute pancreatitis. Methods A total of 60 mild to moderate acute pancreatitis admitted to our hospital from October 2019 to November 2021 were selected and randomly divided into two groups: control group (30 cases) and traditional Chinese medicine group (30 cases), and the plasma inflammatory mediators before treatment and 8 days after treatment were measured respectively. Levels of TNF-α, IL-6, procalcitonin, C-reactive protein, D-lactate and plasma amylase and lipase, gastrointestinal function indicators (fasting time, first exhaust time, first defecation time) , SICU stay time, TCM symptom score, TCM symptom curative effect evaluation.Results The plasma IL-6, TNF-a, procalcitonin, C-reactive protein, amylase, lipase and D-lactic acid in the traditional Chinese medicine group were significantly lower than those in the control group at 8 days after treatment (P <0.05). 8 days after treatment, the stay time of SICU in the TCM group was significantly shorter than that in the control group, and there was a significant difference between the two groups (P <0.05). The fasting time, first exhaust time, and first defecation time in the TCM group were shorter than those in the control group, with significant differences (P <0.05). The evaluation results of TCM efficacy of the two groups showed that in the TCM group, 24 cases (80%) were clinically cured, 5 cases (16.67%) were markedly effective, and 1 case (3.33%) was effective. 14 cases (46.67%) were clinically cured, 13 cases (43.33%) were markedly effective, 3 cases (10%) were effective, and the curative effect of the traditional Chinese medicine group was better than that of the control group (P <0.05). The total scores of TCM symptoms in the two groups after treatment were lower than those in the same group before treatment (P <0.01). Comparing the difference in the total score of TCM symptoms before and after treatment between the two groups, the total score of TCM symptoms was lower in the TCM group.The TCM group had certain benefits over the control group as the therapeutic effect improved. Conclusion Early application of Qingre Tongxia method combined with acupuncture to reduce the level of inflammatory mediators in the plasma of mild to moderate acute pancreatitis. The technique which improve the intestinal mucosal barrier and shorten the duration of SIRS has clinical value.
