Meta analysis on the clinical efficacy of Dachaihu decoction plus endoscopic duodenal for acute biliary pancreatitis with syndrome of damp-heat in liver and gallbladder
MENG Ying，LIU Bao-qing，ZHANG Dong
Beijing University of Chinese Medicine，Beijing(100029), China
Abstract:
Objective To evaluate the effectiveness of modified Dachaihu decoction plus endoscopic duodenal for the treatment of acute biliary pancreatitis(ABP) with syndrome of damp-heat in liver and gallbladder by Meta-analysis. Methods The Pubmed, Cochrane Library, Web of Science, CNKI, VIP, Wanfang data and CBM databases were retrieved from the time of database establishment to June 2022. Two reviewers screened the literatures, extracted data and evaluated the bias of the included trials independently. Afterwards, using RevMan 5.3 software, the meta-analysis was conducted. Results A total of 5 trials involving 463 patients were included into the analysis. The analysis results shows that modified Dachaihu decoction plus endoscopic duodenal for the treatment of ABP with syndrome of damp-heat in liver and gallbladder had stronger effect on increasing overall effective rate[OR=3.75, 95%CI(2.13, 6.62), P＜0.001], shortening the recovery time of amylase in blood [MD=-0.45, 95%CI(-0.64, -0.26)，P＜0.001] and in urine [MD=-1.31, 5%CI(-2.11, -0.52), P=0.001], shortening the abdominal distension relief time [MD=-0.59，95%CI(-0.95, -0.24)，P＜0.001], shortening the abdominal pain relief time [MD=-0.34, 95%CI(-0.48,-0.20), P＜0.001], shortening the first defecation time[MD=-0.71, 95%CI(-1.36, -0.07), P=0.03]，and reducing the score of APACHE-Ⅱ[MD=-1.34, 95%CI(-1.68, -0.99)，P＜0.001]. And the differences were statistically significant. Conclusion The treatment of modified Dachaihu decoction plus endoscopic duodenal has a certain effect on the ABP with syndrome of damp-heat in liver and gallbladder in increasing overall effective rate, rapidly alleviating symptoms and shortening the recovery time of various indicators. But the quality of the included literatures is low, and the conclusion needs more RCTs of high quality to give a further verification.
