Chinese Medicine Intervene in the Treatment of Lower Extremity Venous ulcer :A Meta-analysis
WANGJi-xue,ZHOU Tao,YANG Xi-rui
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China.
Abstract:
Objective To evaluate the efficacy and safety of traditional Chinese medicine intervention combined with surgery in the treatment of lower extremity venous ulcer. Methods Searching the databases of CNKI, Wanfang, VIP, CBM, PubMed, EMBASE and the Cochrane Library, we searched for relevant literatures,screened the randomized controlled trials that met the inclusion criteria, and used Stata 15.1 software to extract the relevant data of effect indicators and conduct statistical analysis. Results a total of 15 articles were included in this study, including 1 097 patients with venous ulcers of the lower limbs, including 552 patients in the treatment group and 545 patients in the control group. All patients in the control group underwent surgical treatment or routine cleaning and dressing change; All patients in the treatment group were treated with traditional Chinese medicine (external treatment, internal treatment and combination of internal and external treatment) combined with surgery for 3 days to 3 months. Results TCM intervention could significantly improve the clinical efficacy [ARR=-0.13(-0.18, -0.09), I2=0.0%, P =0.627, NNT=-8(-11, -6)], shorten the ulcer healing time [SMD=-1.52(-2.08,-0.97), P <0.001], and reduce the ulcer area [SMD=-1.69(-3.27, -0.11), P =0.036]; There was no significant difference in ulcer recurrence rate between the treatment group and the control group [ARR=-0.14(-0.24,-0.03),I2=0.00%, P =0.868, NNT=-7(-33, -4)]. Conclusion Traditional Chinese medicine intervention combined with surgery can improve the clinical efficacy of surgical treatment of venous ulcer of lower limbs, shorten the healing time of ulcer, reduce the area of ulcer and reduce the recurrence rate of ulcer.
