Arecoline Hydrobromide Promotes Gastrointestinal Motility in Dogs through Central Nervous Vagal Cholinergic System
CHEN Qi-cheng，JIANG Zhi，ZHANG Jun-hong
Abstract:
Objective To investigate the central nervous mechanism of arecoline hydrobromide in enhancing gastrointestinal motility. Methods The stress sensors were implanted in the stomach, antrum, duodenum, jejunum and colon of beagles to record gastrointestinal movement. Chronic venous catheters were implanted in the external jugular vein for drug injection. Lateral ventricular catheters were implanted under the dog brain stereotactic instrument for lateral ventricular drug administration. The effects of intracerebroventricular injection of arecoline hydrobromide (1.25 μg, 2.5 μg and 5 μg) were recorded under anesthesia, conscious state, atropine intravenous injection and after bilateral cervical vagotomy on gastrointestinal contractions in dogs. Results Intracerebroventricular injected arecoline hydrobromide (1.25 μg, 2.5 μg and 5 μg) could enhance the contractile movement of gastric body, gastric antrum, duodenum, jejunum, ileum and colon in both anesthetized and conscious dogs in a dose-dependent manner. Intravenous atropine 50 μg/kg could completely block the enhancing effect of arecoline hydrobromide on gastrointestinal motility in dogs. The enhancement of gastrointestinal motility by intracerebroventricular injection of arecoline hydrobromide can be completely eliminated after bilateral cervical vagotomy. Conclusion The arecoline hydrobromide can promote gastrointestinal movement in dogs through central nervous vagal cholinergic system.
