Meta-analysis of Antibiotics Combined with Xuebijing in Prevention of Bacterial Liver Abscess
LIU Jun,LIU Yu-bo,SUN Yan
Department of Clinical Pharmacy，Tianjin Nankai Hospital，Tianjin 300100，China
Abstract:
Objective Evaluation of efficacy and safety of combination of antibiotics and Xuebijing for prevention of bacterial liver abscess. Methods Randomized controlled trials (RCT) of combination of Xuebijing and antibiotics for prevention of bacterial liver abscess were searched from PubMed, Cochrane Library, CNKI, EMbase, VIP and Wanfang database from January 2000 to October 2021. According to the inclusion and exclusion criteria, the data was extracted and processed by RevMan 5.4 Results Six randomized controlled trials involving 494 patients were enrolled. The results of Meta-analysis showed that combined group could significantly shorten temperature recovery time[MD=-1.99, 95% CI(-2.78, -1.21), P ＜ 0.001], shorten WBC level recovery time[MD=-1.26, 95% CI(-1.51, -1.01), P ＜ 0.001], shorten liver function recovery time[MD=-3.01, 95% CI(-3.7, -2.32), P ＜ 0.001]. Conclusion Based on the current clinical evidence, the combination of antibiotics and Xuebijing had better effects on bacterial liver abscess. These findings require more high-quality and large multicenter randomized controlled trials to verify.
