Distribution and Drug Resistance Change of Pathogens of Bloodstream Infections from 2018 to 2021 in Nankai Hospital
XUE Hai-ling，FANG Jie，CHEN Ming-hui
Abstract:
Objective To analyze the distribution and drug resistance of pathogens isolated from bloodstream infections from 2018 to 2021. Methods The blood culture samples in Tianjin Nankai Hospital between 2018 and 2021 were collected. The bacterial identification and antimicrobial susceptibility test were carried out by VITEK 2 Compact. The results were interpreted according to CLSI (2020) breakpoints, and the data was analyzed by WHONET 5.6. Results A total of 2 383 strains of pathogenic bacteria were isolated from the blood samples, including 1 147 strains of Gram-negative bacteria (48.13%) , 1 141 strains of Gram-positive bacteria (47.88%) and 95 strains of fungi (3.99%). The top five most frequently isolated pathogens were Escherichia coli (21.78%), Staphylococcus hominis (15.00%), Klebsiella pneumoniae (12.59%), Staphylococcus epidermis (9.74%) and Enterococcus faecium (4.97%). The resistant rates of Escherichia coli and Klebsiella pneumoniae to carbapenems were 0.58% and 12.67% respectively. Among non-fermentative bacteria, Pseudomonas aeruginosa and Acinetobacter baumanni，the resistant rates were 52.94% and 60.00%. The detection rates of methicillin-resistant in Staphylococcus aureus and in coagulase-negative Staphylococcus aureus were 26.67% and 72.77% respectively. The Vancomycin- and tegacycline-resistant Staphylococcus spp.was not found. The resistance of Enterococcus to vancomycin, tegacycline and linezolid were all low. Conclusion The Gram-negative bacteria were most frequently isolated from bloodstream cultures and showed an increasing tendency during the past 4
