Observation of the Effects of Chaizhi Pinggan Decoction on the Levels of Gastrointestinal Hormones and NPSR1 in Functional Dyspepsia Patientswith Disharmony between Liver and Stomach
WEI Wei,WEI Jing-jing,YUAN Hong-xia
Tianjin University of Traditional Chinese Medicine,Tianjin (301617), China
Abstract:
ObjectiveTo analyze the therapeutic effect of traditional Chinese medicine Chaizhi Pinggan Decoction in functional dyspepsia patientswith disharmony between liver and stomach, as well as the actual effect on the levels of gastrointestinal hormones and serum neuropeptide S receptor-1 (NPSR1). Methods Patients were extracted from January 2020 to January 2021 in Tianjin Second People' s Hospitaland First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, which 76 cases of patients were functional dyspepsia liver stomach. They were divided into control group and observation group by random number table method.The control group were given conventional western medicine treatment and the observation group were combined with Chaizhi Pinggan Decoction.Total effective rate, gastrointestinal hormone levels and NPSR1 level changes before and after treatment of the two groups were compared. Results The total effective rate was 97.37% in the observation group and 81.58% in the control group (P< 0.05). Before treatment, the levels of 5-HT, SS, PG Ⅱ and NPSR1 in the two groups were compared (P> 0.05). Aftertreatment, the levels of 5-HT, PG Ⅱ and NPSR1 in the observation group were higher than those inthe control group, while the level of SS was lower than that in the control group (P<0.05). Conclusion The application of Chaizhi Pinggan Decoction in functional dyspepsia patientswith disharmony between liver and stomach can significantly enhance the efficacy,The mechanism may be related to its regulation to gastrointestinal hormone levels and NPSR1 level.
