Observation on Curative Effect of Mexinzodone Suppository Combined with Chinese Medicine Oral and External Washing in Patients with Anal Papilla Hypertrophy and Its Influence on TCM Syndrome Score
LIU Li-ting,QIN Peng-pai
Another Ward, Beijing Anorectal Hospital Beijing Erlong Road Hospital, Beijing 100032, China
Abstract:
Objective To investigate the curative effect of mexinzodone suppository combined with traditional Chinese medicine oral and external washing in patients with anal papilla hypertrophy and its influence on TCM syndrome score. Methods 124 patients with anal papilla hypertrophy from April 2018 to January 2020 were randomly divided into two groups, 62 cases in each group. All patients were planned to undergo surgical treatment. The control group was treated with methimazole suppository, while the observation group was treated with oral and external washing of traditional Chinese medicine on the basis of the control group. After one month of treatment, the effect of the patients was evaluated and 6-month follow-up was completed. TCM syndrome score, inflammatory factor level, anorectal motility level, incidence of adverse reactions and recurrence rate were compared between the two groups. Results One month after treatment, edema (0.81±0.15), pain (0.94±0.18), granulation morphology (0.74±0.12), wound exudate (0.91±0.17) and anal drop score (0.71±0.11) in the observation group were lower than those in the control group (t = 8.012, 6.396, 7.889, 6.846, 6.921, all P<0.001). The IL-1 (6.27±0.22) and IL-6 (22.14±2.17) in the observation group after 4 weeks of treatment, the levels of TNF -α(13.25±1.09) and CRP (1.12±0.16) in the control group were lower than those in the control group (t =8.112, 7.295, 9.341, 7.934, P<0.001). The incidence of nausea and vomiting, blood pressure fluctuation and abnormalliver and kidney in the two groups were 3.23% and 4.84% respectively, with no statistical signi?cance (χ2=0.208, P=0.648). The recurrence rates at 1 and 3 months after treatment in the two groups were not statistically signi?cant (χ2=1.008, 0.342, P=0.315, 0.559). The recurrence rate in the observation group was lower than that in the control group 6 months after treatment (χ2 = 3.916, P=0.048). Conclusion It can reduce the TCM syndrome score, improve the level of inflammatory factors, improve the level of anorectal motility in patients with anal papilla hypertrophy, without increasing the incidence of adverse reactions, which is helpful to reduce the recurrence rate.
