Efficacy and Prognosis of Cinobufacini Microspheres Combined with Cisplatin Chemoembolization and Doxorubicin in the Treatment of Hepatocellular Carcinoma
JIANG Yang,HE Xian-lu,XIA Xu-liang
Hepatobiliary Vessels Department,The Second Affiliated Hospital of Chengdu Medical College · Nuclear Industry 416 Hospital, Chengdu610051,China
Abstract:
Objective To evaluate the efficacy and prognosis of Cinobufacini microsphere combined with CISPLATIN and doxorubicin in transcatheter arterial chemoembolization (TACE) for hepatocellular Carcinoma (HCC). Methods 60 patients with liver cancer admitted to our hospital from October 2018 to October 2019 were randomly divided into two groups. The patients in the control group (30 cases) were treated by TACE with doxorubicin and CISPLATIN, after TACE with Cinobufotalin microsphere + CISPLATIN + doxorubicin in 30 patients in the observation group. The liver function, survival rate, total efficacy, adverse reaction and peripheral blood T lymphocyte were observed. Results After treatment, the levels of ALT, AST and TBIL in the observation group were better than those in the control group (t=2.634, 2.509, 3.196, P<0.05) and there was no statistical significance (t=0.262, P>0.05). After treatment, the survival rates of the patients in the observation group at 3,6,9 months and 1 year were significantly higher than those in the control group and there were statistical significance (χ2 =10.755,10.800,10.000,9.773, P<0.05). After treatment, the curative effect of the two groups was 76.66%, 46.66% respectively, which the observation group was significantly higher. The total incidence of adverse reactions were 10.00%, 33.33% respectively, which the observation group was significantly lower (P<0.05). After treatment, the ratio of CD3+ and CD4+ in the observation group was higher than that in the control group before treatment (P <0.05), and the change of CD8+ in the control group was not significant (P>0.05). Conclusion Cinobufacini microsphere combined with CISPLATIN and doxorubicin can effectively improve the level of liver function index, improve the survival rate and immune function of patients with liver cancer, and the incidence of adverse reactions is relatively low. It has higher safety, better clinical curative effect and disease prognosis effect, which is worth popularizing.
