Application of Xiaozhuo Huashi Decoction Combined with Flexible Ureteroscope in Patients with Kidney Stones and its Influence on Inflammatory Factors
WU Xiao-fang
Department of Urology Surgery, the First People' s Hospital of Chun' an County, Hangzhou, Zhejiang 311700, China
Abstract:
Objective To explore the application effect of Xiaozhuo Huashi Decoction combined with flexible ureteroscope in patients with kidney stones and its influence on inflammatory factors. Methods Ninety-four patients with kidney stones from May 2018 to July 2019 were selected as subjects, and they were divided into two groups by random number table, with 47 cases in each group. The control group was treated with flexible ureteroscopy, and the observation group was treated with Xiaozhuo Huashi Decoction on the basis of the control group. After 14 days of treatment, the effect was evaluated and a 12-month follow-up was completed. The scores of TCM syndromes, inflammatory factors, complications and recurrence rates were compared between the two groups. Results 14 days after treatment in the observation group, waist and abdomen colic (0.95±0.23) points, astringent urination (1.23±0.37) points, urinary weakness (1.15±0.32) points, blood in the urine (0.91±0.19) points, dry stools (0.67±0.11) points and mental fatigue score (0.84±0.25) points were lower than those of the control group [waist abdominal cramps (1.98±0.43) points, astringent urine (2.32±0.43) points, urination weakness (2.96±0.51) points, blood in the urine (2.69±0.47) points, dry stools (2.41±0.45) points and fatigue score (1.68±0.16) points] (t=7.132, 6.339, 8.571, 6.983, 6.484, 5.983, P<0.05). 14 days after treatment, the inflammatory factor IL-6 level (8.12±0.79) pg/mL and CRP level (5.41±0.49) mg/L of the observation group were lower than those of the control group [IL-6 level (13.21±1.68) pg/mL and CRP level (13.98±2.51) mg/L] (t=4.349, 5.319, P<0.05). The IL-10 level (15.93±3.41) ng/L is higher than that of the control group (11.12±2.59) ng/L (t=6.645, P<0.05). The incidence of infection, bleeding and hemorrhagic shock during the treatment of the two groups were not statistically significant (P>0.05). The recurrence rate of the two groups at 1 and 6 months after the course of treatment were not statistically signi?cant (P>0.05). The recurrence rate of the observation group was lower than that of the control group after 12 months of treatment (P<0.05). Conclusion Xiaozhuo Huashi Decoction combined with ?exible ureteroscopy can reduce the TCM syndrome scores of patients with kidney stones, help reduce the level of in?ammatory factors, without increasing the incidence of complications, which can reduce the recurrence rate after treatment. It is worthy of popularization and application.
