Effects of Zoledronic Acid Combined with Bushen Huoxue Decoction on Bone Mineral Density and Biochemical Markers of Bone Metabolism in Patients with OVCF during Recovery Period
BU Bin,BU Lin-lin,WANG Yan
Orthopaedics Department, People' s Hospital of Zhangwan District, Shiyan, Hubei (442002),China
Abstract:
Objective To evaluate the effect of zoledronic acid (zoledronic acid) and Bushen Huoxue decoction on postoperative rehabilitation of patients with osteoporotic vertebral compression fracture (OVCF). Methods In this study, 80 patients with OVCF underwent surgery from March 2019 to May 2020.According to the method of random number table, 40 patients in control group were given zoledronic acid after operation, and 40 patients in observation group were given zoledronic acid + Bushen Huoxue decoction.The changes of bone mineral density (BMD), bone metabolism and biochemical indexes were observed. Results The visual analogue scale (VAS) and Oswestry dysfunction index (ODI) of 30 days after operation in the observation group were lower than those in the control group(P<0.05). At 30 days after operation, the BMD of the femoral neck and lumbar vertebrae in the observation group were higher than those in the control group, and the COBB angle was lower than that in the control group(P<0.05). The levels of Osteocalcin (BGP) and bone specific Alkaline phosphatase (BGP) in the observation group were higher than those in the control group at 30 days after operation. The levels of type I collagen cross-linked Amino Terminal Peptide (NTX I) and type I collagen cross-linked carboxyl Terminal Peptide (CTX I) in the observation group were lower than those in the control group, which the differences were statistically significant(P<0.05). Conclusion The OVCF patients were treated with zoledronic acid and Chinese herbs Bushen Huoxue decoction after operationcan could obviously improve the effect of pain relief, improve the degree of LUMBAR dysfunction, promote the increase of bone density, improve the bone metabolism and help the patients to get better rehabilitation.
