Effects of Danggui Tongbi Decoction Combined with Traditional Chinese Medicine Hot Compress on Knee Osteoarthritis and the Levels of IL-1β, MMP-3 and TNF-α Level
REN Jing-pei,MU Xiao-hong,LI Jin-yu
Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine 100700, China
Abstract:
Objective To investigate the effect of Danggui Tongbi decoction combined with traditional Chinese medicine hot compress on knee osteoarthritis and its effect on IL-1β,MMP-3 and TNF-αlevels. Methods 140 patients with osteoarthritis of the knee in our hospital were selected and randomly divided into two groups with 70 cases each. The control group was treated with hot compress of traditional Chinese medicine, and the treatment group was treated with Danggui Tongbi decoction on the basis of the control group. The clinical efficacy, VAS score, WOMAC index and ADL score, as well as the levels of IL-1β,MMP-3 and TNF-α after treatment were compared. Results After treatment, the total effective rate was higher in the treatment group (P<0.05).The WOMAC index and VAS score were significantly decreased and ADL score was significantly increased in the two groups (P<0.05). The improvement degree of the treatment group was greater (P<0.05).The IL-1β,MMP-3 and TNF-αlevels were significantly reduced in the two groups (P<0.05). In addition, the degree of reduction in the treatment group was lower than that of the control group (P<0.05). There was no statistical significance in the incidence of adverse reactions between two groups (P>0.05). Conclusion The application of Danggui Tongbi decoction combined with traditional Chinese medicine hot compress in the treatment of knee joint osteoarthritis has a good clinical effect and can improve the knee joint function of patients, which is worthy of clinical application.
