Study on the Effect of High-Dose and Fractionated Radiotherapy in Patients with Pancreatic Cancer after Surgery and its Impact on Survival
LIU Li-hua
Department of Oncology, Heze Hospital of Traditional Chinese Medicine, Heze, Shandong 274000, China
Abstract:
Objective To explore the effect of high-dose and fractionated radiotherapy in patients with pancreatic cancer after surgery and its impact on survival. Methods Seventy-eight patients with pancreatic cancer from February 2015 to February 2018 were selected as subjects. The random number method was divided into a control group (n=39 cases) and an observation group (n=39 cases). Both groups underwent surgical treatment. The control group was treated with conventional chemotherapy after operation. The observation group was treated with a high-dose and small-fraction radiotherapy model based on the control group. The effect of the patients was evaluated after 3 courses of treatment. Both groups were completed after treatment. Followed up for 24 months, the short-term ef?cacy, quality of life, incidence of side effects and survival rate were compared between the two groups. Results The curative effect rate of the 3 treatment courses of the observation group was 66.67%, which was higher than that of the control group 41.03% (χ2=6.734, P=0.026). The weight loss (42.41±3.59) and fatigue (31.54±3.26) of the 3 treatment courses of the observation group after treatment, pain points (19.77 ± 3.61), abdominal distension points (35.34± 4.11), diarrhea points (13.49 ±3.13) and appetite loss score points (28.48±3.59) were lower than those of the control group, which were weight loss (55.79±4.22), fatigue points (45.69±4.12), pain points (32.14±4.03), abdominal distension points (43.15±4.25), diarrhea points (18.53±3.69) and appetite loss score points (38.51±4.31) (t=6.392, 5.416, 7.498, 6.121, 5.983, 7.335, P=0.032, 0.036,47，0.022, 0.030, 0.044, 0.023). The incidence of leukopenia, radiation enteritis, radiation dermatitis, platelet reduction and abnormal liver and kidney function during the treatment of the observation group and the control group were not statistically signi?cant (occurrence rates were 33.33% vs 38.46%) (χ2=1.215, P=0.592). The observation group had a 12-month survival rate of 69.23%, a 24-month 41.03% survival rate, PFS (12.59±2.31) months and OS survival The period (7.83±1.15) months were longer than those of the control group, which 12-month survival rate 53.85%, 24-month 30.77% survival rate, PFS (6.43±1.04) month and OS survival period (4.36±0.85) month (χ2=6.317, 4.926 , t=5.637, 7.112, P=0.034, 0.041, 0.029, 0.011). Conclusion The high-dose, low-fractionated radiotherapy model can be used in patients with pancreatic cancer after surgery to obtain higher short-term ef?cacy, improve the patient' s quality of life after surgery, improve the patient' s long-term survival rate, and do not increase the incidence of toxic and side effects. It is worth promoting.
