Effects of Tongfu Chengqi Decoction on Serum Inflammatory Factors and Gastrointestinal Function Recovery in Patients with Early Postoperative Inflammatory Bowel Obstruction
ZHANG Liang,SUN Naihui
Third Surgical Department, Tianjin Ninghe District Hospital, Tianjin 301500, China
Abstract:
Objective To investigate the effects of Tongfu Chengqi plus or minus decoction on the clinical efficacy and adverse reactions of patients with early postoperative inflammatory bowel obstruction. Methods Eighty-four patients with early postoperative inflammatory bowel obstruction from March 2018 to March 2020 in our hospital were divided into a conventional group (routine treatment of inflammatory bowel obstruction by Western medicine) and Tongfu Chengqi decoction group (conventional treatment plan with addition or subtraction of Tongfu Chengqi Decoction) according to the random number table method, which 42 cases in each group. The curative effect, gastrointestinal function recovery and adverse reactions of the two groups after treatment, and serum inflammatory factor indicators before and after treatment [Supersensitive C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), procalcitonin (PCT)] were compared. Results After treatment, the total clinical efficacy of Tongfu Chengqi decoction group was 88.10% (37/42), which significantly higher than that of the conventional group 71.43% (30/42). Recovery time of song, time of disappearance of abdominal symptoms (abdominal pain and bloating), time of anal exhaust and gastric tube evacuation were longer than those of Tongfu Chengqi decoction group (3.56±0.87) vs (2.14±0.43) d, (5.79±1.02) vs (3.58±0.84) d, (4.69±1.10) vs (3.05±0.97) d, (6.43±1.78) vs (4.09±1.12) d and there are differences in comparison (P<0.05). The total incidence of adverse reactions in the conventional group and the Tongfu Chengqi decoction group was 4.76% (2/42), 7.14% (3/42), which no difference in comparison(P > 0.05). Before treatment, there was no difference in serum hsCRP, TNF-α, IL-8 and PCT levels between the two groups (P > 0.05). After treatment, the levels of serum hsCRP, TNF-α, IL-8 and PCT in Tongfu Chengqi decoction group were lower than those of the conventional group(30.43±8.76) vs (61.26±11.32) mg / L, (24.75±9.86) vs (43.07±12.14) ng/mL, (67.64±21.32) vs (98.77±28.96) pg/mL, (70.06±15.34) vs (125. 63±19.48) pg/mL and there are differences in comparison (P <0.05). Conclusion The clinical application of Tongfu Chengqi decoction in patients with early postoperative inflammatory bowel obstruction can not only shorten the time required for the recovery of gastrointestinal function and alleviate in?ammatory reactions, but also improve clinical ef?cacy. Signi?cantly increased, the safety is acceptable, and it has certain clinical usage and promotion value.
